This is unpublished

Ming
Lam
PhD

Faculty
Pinned
Academic
Research Associate Professor

Biography

Dr. Lam’s research program is to uncover the biology underlying distant metastases and treatment response, and identify actionable targets for castration-resistant prostate cancer and bladder cancer. The goal is to rationally devise novel therapeutic strategies to improve survivorship of patients affected by cancer. Dr. Lam’s focus areas include:

 

Image of bladder cancer metastasis (up) and spatial transcriptional profiling of tumor and its tumor microenvironment (bottom)
Image of bladder cancer metastasis (up) and spatial transcriptional profiling of tumor and its tumor microenvironment (bottom)
  1. Tumor interaction with microenvironment at metastatic sites.  We are interested in investigating how microenvironment regulates tumor dormancy and support tumor growth in distant metastases.

 

  1. Identification of treatment response and resistance. Treatment response is diverse among patients or even within different metastatic sites of patients, suggesting tumor heterogeneity. We utilize clinical specimens, cell models, and patient-derived xenografts to systematically identify treatment targets, response, and resistance.

     

  2. Bladder cancer rapid autopsy program and biorepository. This is a multi-disciplinary effort among urologists, medical oncologists, pathologists, translational scientists, and computational biologists to partner with patients and accrue biospecimens from patients with bladder cancer. This invaluable resource is critical for understanding the disease and for much needed therapeutic discovery.

 

Memberships

American Association for Cancer Research
American Urological Association
Seattle Tumor Translational Research (STTR)
Fred Hutchinson/University of Washington Cancer Consortium
Society of Chinese Bioscientists in America (SCBA)
Society for Basic Urological Research (SBUR)

 

Research highlights

 

Selected publications

Cancer metastases and preclinical models

 


Cancer interaction with microenvironment at metastatic sites


Estrogen receptor signaling in prostate cancer